Previous reports have shown that inhibition of

2018-10-20

Previous reports have shown that inhibition of GSK3 by CHIR promotes mESC self-renewal through activation of Wnt/β-catenin signaling pathway (Martello et al., 2012). In the absence of Wnt ligand or CHIR, T cell factor 3 (TCF3) occupies the promoter regions of many pluripotency genes (e.g., Nanog, Es

However PSCs have major safety concerns such as teratoma

2018-10-20

However, PSCs have major safety concerns, such as teratoma formation due to possible contamination of the residual undifferentiated PSCs (Lee et al., 2013a). Teratoma is a unique characteristic of PSCs owing to their pluripotency and ability to undergo unlimited proliferation (Gruen and Grabel, 2006

Researchers are usually aware of the tissue that was

2018-10-20

Researchers are usually aware of the tissue that was initially used for isolation of MSCs, but there is evidence that accidental interchange of samples or contaminations with other GSK256066 can occur (Garcia et al., 2010; Torsvik et al., 2010). For established cell lines, some contaminations can b

The inhibition of differentiation has been considered to pla

2018-10-20

The inhibition of differentiation has been considered to play a role in many types of tumor development through maintenance of the proliferating progenitor cell state. Previous studies demonstrated that the knockdown of EWS-FLI1 in Ewing sarcoma cell lines results in osteogenic, adipogenic and chond

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2018-07-29