• Despite taking hydroxyurea for months his leukocytosis

  2019-05-05

  

  Despite taking hydroxyurea for 6 months, his leukocytosis, splenomegaly, and constitutional symptoms were poorly controlled and his performance status and overall function had declined even further. There was little clinical benefit to gain by increasing the hydroxyurea dose further especially in th

• To overcome these resistance mechanisms in APL

  2019-05-05

  

  To overcome these resistance mechanisms in APL cells, a number of drugs have been tested. Tamibarotene is approximately 10 times more potent than ATRA as an in vitro inducer of differentiation, and is chemically more stable than ATRA [5]. Although the precise mechanism of the combination of tamibaro

• Friberg et al have indicated that

  2019-05-05

  

  Friberg et al. [17] have indicated that the CHA2DS2-VASc score is superior to the CHADS2 score in terms of stroke risk stratification, and the risk of stroke is extremely low among patients with a CHA2DS2-VASc score of 0 in whom antithrombotic therapy is not beneficial and may even increase the risk

• Approximately of the patients who developed BM during

  2019-05-05

  

  Approximately 50% of the patients who developed BM during their palliative disease course received BM-related radiotherapy and/or surgery; 12% of the patients received both therapy options. Our data confirms that the majority of patients with BM will respond to a low course of radiotherapy with good

• In this context in Heather Zar

  2019-05-05

  

  In this context, in , Heather Zar and colleagues report findings from the first study to assess the accuracy of Xpert MTB/RIF in young children presenting to a primary-care facility with symptoms of pulmonary tuberculosis. Primary analysis was done in 309 children in whom four samples (two induced s

• is a fastidious organism requiring specific nutritional atmo

  2019-05-05

  

  is a fastidious organism requiring specific nutritional, atmospheric, and temperature requirements for growth. For this reason culture capability might only be available in limited PICT microbiology laboratories. The use of multiplex PCR targeting common pathogens associated with genital ulceration—

• La reivindicaci n del m rtir revolucionario El

  2019-05-05

  

  La reivindicación del mártir revolucionario El proceso del egp dio lugar Erastin consolidar un frente de estudiantes constituido con su línea política, trabajo continuo del estudiantado identificado con ello; respecto a la dirección de esta organización, carecemos de comunicados o publicaciones que

• En la condensaci n del

  2019-05-05

  

  En la condensación del “Borges y yo” se despliega un texto que tanto puede ser considerado perteneciente al orden de la narrativa como al orden del ensayo, e incluso al de la poesía. En palabras de José Miguel Oviedo, “es un cuento que es también un ensayo que es también un poema”. “No sé quién de l

• br Materials and methods br Results and discussion ABT is

  2019-05-05

  

  Materials and methods Results and discussion ABT-737 is a BH3-mimetic targeting Bcl-2, Bcl-XL and Bcl-W. The aim of the experiments was to test whether inhibition of Bcl-2 and Bcl-XL using ABT-737 can eradicate the CD34+/CD38− AML cell population. Bone marrow MNCs from patients (Table 1) were

• In our study acute toxicities were

  2019-05-04

  

  In our study, acute toxicities were mild, and there were no Grade 3 or above hematologic toxicities. Only one patient (3.2%) had Grade 3 esophagus toxicity and three patients (9.7%) had Grade 3 lung toxicity. Compared with studies that investigated regimens of oxaliplatin and 5-FU/leucovorin, the pr

• br Tara Mangal and colleagues document the

  2019-05-04

  

  Tara Mangal and colleagues document the struggle to eliminate polio in northern Nigeria. However, they overlook the importance of routine immunisation to polio eradication efforts. The investigators identified an association between the risk of contracting polio and oral polio vaccine unavailabil

• A first step forward would be to establish

  2019-05-04

  

  A first step forward would be to establish a public-health-oriented commission or agency charged specifically with developing controls over the alcohol market and a strategy for reducing levels of alcohol consumption and problems, drawing on the strategies agreed on in the WHO Global Strategy for Re

• Forskolin Cuando Gonzalo Pizarro se alz

  2019-05-04

  

  Cuando Gonzalo Pizarro se alzó en el Perú, nunca mostró intenciones de romper los vínculos que lo unían Forskolin su rey, por mucho que su plan fuese establecer una monarquía, autónoma de la castellana, que gobernaría el territorio. En las misivas que envió al monarca, Pizarro confirmaba su obedienc

• br Intrauterine insemination IUI is one of

  2019-05-04

  

  Intrauterine insemination (IUI) is one of the more widely used fertility treatments, and often suggested as the first choice for infertile couples with cervical infertility, mild male factor infertility, anovulation, mild or minimal endometriosis, and unexplained infertility with at least one pate

• Ja s et al reported that complete

  2019-04-30

  

  Jaïs et al. reported that complete LAVA elimination is a better predictor of success than the absence of inducibility [23]. Achieving complete elimination of LAVA yields superior survival free from recurrent VT during long-term follow-up. Scar homogenization significantly increases the freedom from

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