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thymidylate synthase We report a case of DCML
2019-04-23
We report a case of DCML deficiency and MDS in a patient with GATA2 mutation who successfully underwent allogeneic stem cell transplantation. Case report At presentation, she had adapted to a hemoglobin level of 79g/l and had only occasional discrete symptoms of her anemia, as fatigue, other con
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MC1568 Case report A previously healthy
2019-04-23
Case report A previously healthy 37-year-old man was referred to our hospital in September 2015 with fever (between 37 and 38°C) for 10 days and general malaise. There was no history of recent travel, and the patient had no animals in his home. There were no remarkable features in the heart, lungs,
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There is strong agreement that HIV prevention
2019-04-22
There is strong agreement that HIV prevention should focus on approaches that are evidence based, but there is disagreement about how to obtain such rigorous evidence and whether this should refer only to randomised study designs. Pickles and colleagues\' report provides a concrete example of an eff
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br Conformational control inhibition Conformational escape r
2019-04-22
Conformational control inhibition Conformational escape resistance is a phenomenon where point mutations (such as T315I) drive the Abl kinase toward the active type I state. “Switch-control inhibitors” bind in a non-ATP-competitive fashion to residues (E282, R386) the Abl protein uses to switch b
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br Methods br Results br Discussion A baumannii remains
2019-04-22
Methods Results Discussion A. baumannii remains one of the most common nosocomial pathogens and frequent causes of outbreaks in burn wound infections. Unfortunately, most of the isolates are resistant to antimicrobial agents. β-Lactamases are microbial enzymes that hydrolytically inactivate
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factor xa inhibitors br Discussion There are many reports on
2019-04-22
Discussion There are many reports on the effectiveness of pacing therapy for hypertrophic obstructive cardiomyopathy. Fananapazir et al. reported that long-term right ventricular apical pacing improved both the left ventricular outflow tract gradient and subjective symptoms [3]. Maron et al. repo
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In patients with typical atrial
2019-04-22
In patients with typical atrial flutter circulating around the tricuspid valve, the verification of a bidirectional conduction block is recommended for cavotricuspid isthmus (CTI) ablation, because a unidirectional conduction block at the CTI has been previously reported to cause recurrence of atria
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Another mechanism is that J waves represent a
2019-04-22
Another mechanism is that J waves represent a repolarization abnormality where J waves are created by the transmural voltage gradient [16]. During myocardial ischemia, the membrane ionic currents are known to be augmented, in turn augmenting the transient outward current (Ito). Augmented Ito would r
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br Conclusion br Conflict of interest br
2019-04-22
Conclusion Conflict of interest Introduction Radiofrequency catheter ablation has been established as an effective and curative therapy for Wolff-Parkinson-White Syndrome [1–4]. Therefore, prediction of the precise location of an accessory pathway (AP) prior to the ablation procedure is of
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br Authors disclosure Mark Clemons received
2019-04-22
Authors\' disclosure Mark Clemons received honoraria for talks from Novartis and Amgen, research funding from Novartis. Case In September 2007 a 9½-year-old boy was diagnosed with a Ewing sarcoma (EWS-FL1 translocation positive) of the right scapula. MRI showed a tumor of 8.0×2.9 ×6.2cm locat
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br Conclusion br Conflicts of interest br Clinical case The
2019-04-22
Conclusion Conflicts of interest Clinical case The worldwide estimated prevalence of cardiovascular implantable electronic device (CIED) infection is 1–2%. Prompt removal of infected devices ensures survival [1–4]. We report successful extraction of a lead from an infected CIED by using an
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We built and improved on previous models of research capacit
2019-04-22
We built and improved on previous models of research capacity strengthening and used an integrated approach not only focused on individual researchers or providing technical assistance but also on fostering an institutional environment that hif inhibitor is supportive of safe and ethical science. O
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The Millennium Development Goals MDGs
2019-04-22
The Millennium Development Goals (MDGs) have become key targets for the international Silvestrol over the past 15 years. The MDGs have raised awareness, focused global efforts on agreed priorities, and empowered so-called development champions at country level. This progress was less straightforwar
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br Point of care diagnostic tests POCTs can enable health
2019-04-22
Point-of-care diagnostic tests (POCTs) can enable health-care workers to provide more rapid and effective care to people in low-resource settings. POCTs should ideally meet the WHO\'s ASSURED criteria—ie, being affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and d
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bruton\'s tyrosine kinase Para Estados Unidos Argentina
2019-04-22
Para Estados Unidos, Argentina no ha sido comercialmente relevante bruton\'s tyrosine kinase pesar de que ocupó el puesto 29 entre sus destinos de exportación, y que las ventas norteamericanas aumentaron más del doble en relación a lo que importó del país latinoamericano. Incluso, casi 85% del total
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