• In the phase AZURE trial women were randomly assigned to

  2019-04-19

  

  In the phase 3 AZURE trial, 3360 women were randomly assigned to receive standard adjuvant systemic treatment alone (control group) or with 4mg intravenous zoledronic oleuropein every 3–4 weeks for 6 doses, then every 3 months for 8 doses, followed by every 6 months for 5 doses, for a total of 5 ye

• A year old female patient

  2019-04-19

  

  A 55-year-old female patient was referred to us for p2y inhibitor of an implantable cardioverter-defibrillator (ICD) after cardiac arrest due to idiopathic ventricular fibrillation. As she was young and had no indications for cardiac resynchronization therapy or bradycardia support, she was screened

• As la historia a la

  2019-04-19

  

  Así, la historia, a la vez ejemplar e ilustrativa, es un elemento aglutinador de la identidad del pueblo mexicano pues conforma la narración unificadora necesaria para fusionar, en una identidad única, a la sociedad mexicana. Por ello, para Vigil, la enseñanza de la historia convertiría “a los habit

• Feeding stimulates gallbladder contraction emptying its cont

  2019-04-19

  

  Feeding stimulates gallbladder contraction, emptying its contents into the upper part of the small intestine, where CBAs activate pancreatic lipase to release monoglycerides and free fatty acids from triglycerides. Mixed micelles with monoglycerides, fatty acids, cholesterol, and fat-soluble vitamin

• beta-lactamase Data on the costs of mental disorders could m

  2019-04-19

  

  Data on the costs of mental disorders could motivate changes in mental health services. In the UK, economists and clinical researchers showed that increasing access to evidence-based psychological services (eg, cognitive behavioural therapy) would be nearly cost-neutral for the UK Government because

• br Discussion Case reports of

  2019-04-18

  

  Discussion Case reports of successful chemotherapy desensitizations have been described for platinum agents, taxanes, anthracyclines, rituximab [8], and cytarabine [9], but not specifically clofarabine. For older patients with relapsed AML that are not candidates to receive anthracycline therapy,

• br Introduction Incidence of oral cancers accounts for of

  2019-04-18

  

  Introduction Incidence of oral cancers accounts for ∼3% of all malignancies. Oral squamous cell carcinoma (OSCC) accounts for >95% of all malignancies in the oral cavity, and it is the fifth leading cause of cancer death in the male population in Taiwan. OSCC is treated mainly with surgery. Post

• It has been speculated that

  2019-04-18

  

  It has been speculated that the geographical variation among radiotherapy prescription is a function of the respective healthcare systems within each region. If physicians receive greater reimbursement for multiple fractions compared to a single fraction, they will likely have greater willingness to

• br Material and methods br Results

  2019-04-18

  

  Material and methods Results Discussion Conclusions Conflict of interest Acknowledgments Introduction Matching the morphology of paced complexes to tachycardia complexes is useful for mapping arrhythmias. In the atrium, pace mapping is useful for focal atrial arrhythmias in orde

• In addition we demonstrated that the combination of PCBP

  2019-04-18

  

  In addition, we demonstrated that the combination of PCBP2 siRNA and LY2109761 had a potent silencing effect on collagen expression (Fig. 8). Both HSC-T6 NVP-TNKS656 and primary HSCs were used to evaluate the combinational treatment. LY2109761, a TGFβ receptor type I/II kinase inhibitor, has been u

• Si en La virgen de los sicarios

  2019-04-18

  

  Si en La virgen de los sicarios “la vida crapulosa está derrotando ccr2 antagonist la muerte”, y “anda toda ventiada por Medellín día y noche en su afán haciendo lo que puede, compitiendo con semejante paridera, la más atroz [y] este continuo nacer de niños y el suero oral le están sacando canas”, p

• br Tanto en el cuerpo

  2019-04-18

  

  Tanto en el cuerpo principal de la revista como en la sección de análisis de libros y revistas, aparecen artículos y notas de tenor necrológico, los cuales ofrecen una suerte de homenaje póstumo nucleoside analog personajes que generalmente habían actuado en el terreno científico, filosófico o de

• br Case report The patient was an month old

  2019-04-17

  

  Case report The patient was an 11-month-old boy. No abnormalities were observed throughout the embryonic stage and perinatal period. When he was 11 months and 10 day old, he suddenly developed pallor and poor responsiveness, with his eyes rolled back in his head, which continued for approximately

• br Discussion There is an important need for new treatment

  2019-04-17

  

  Discussion There is an important need for new treatment options for AML in elderly patients. Their frailty imposes limitations upon the aggressiveness of the treatment which can be administered [6,24]. In addition, the poor prognostic disease features often seen in this neurotensin receptor mean

• In addition to CAF in

  2019-04-17

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

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