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br Materials methods br Results br Discussion We
2018-11-14
Materials & methods Results Discussion We here demonstrate the clinical applicability of an unbiased mass spectrometry-based platform in the pursuit of identifying low-abundance regulatory peptides such as oxyntomodulin and GLP-1. The platform was used to identify glucose- and appetite-regu
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We have demonstrated that a direct
2018-11-14
We have demonstrated that a direct inhibitor on InhA can retain the outstanding profile of isoniazid and considering the DMPK parameters of both compounds the antitubercular effect is achieved at similar exposures of free drug proving our initial dnmt and overcoming resistances mediated by KatG. GS
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br Introduction Adapter and scaffold proteins rewire signali
2018-11-14
Introduction Adapter and scaffold proteins rewire signaling networks by subcellular compartmentalization and enable spatio-temporal Histone Compound Library to environmental cues that may be derailed in disease conditions like cancer (Good et al., 2011). Docking protein-1 (DOK1) is a versatile a
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The link to dietary protein quality is of
2018-11-14
The link to dietary protein quality is of particular interest from a public health lens; as the authors note, “dietary intake of essential Volasertib may be insufficient in children with stunting”. Previous research supports this hypothesis: An analysis of dietary and anthropometric data collected
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br Genetics of Pain Sensitivity Pain is a distressing feelin
2018-11-14
Genetics of Pain Sensitivity Pain is a distressing feeling often caused by unpleasant stimulation resulting in tissue damage, and is the most common reason for general practitioner consultations in the developed world. Geoff Woods (Cambridge, UK) presented the latest developments in the study of
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Although we are investigating potential
2018-11-14
Although we are investigating potential links between these findings and currently hypothesized models of MS pathobiology, ERY studies in MS patients are not without precedence. A report in the 1960s (Raczkiewicz and Leyko, 1966) documented enhanced production of “adenine nucleotides” from ERYs of M
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In vitro studies using shRNAs to target autophagy regulators
2018-11-14
In vitro studies using shRNAs to target >100 autophagy regulators identified a number of breast cancer cell lines that are dependent upon functional autophagy for growth even in the absence of stress (Maycotte et al., 2014). Importantly however, some tumor cell lines were barely affected by autophag
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br Materials and Methods br Results br Discussion This study
2018-11-14
Materials and Methods Results Discussion This study demonstrates that pharmacological inhibition of PKCθ in 4-week-old mdx mice, significantly prevents muscle wasting and inflammatory response, while maintains muscle regeneration and improves function and performance. We used the C20, one o
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Acknowledgements br Data Anthocyanins in
2018-11-14
Acknowledgements Data Anthocyanins in complexes with gallic/ferulic/caffeic acids were evaluated using an accelerated stability test at 95°C, and sampled at regular intervals (0, 0.5, 1, 2, 5, 10, and 15h). Fig. 1.1 shows the color appearance of anthocyanin complexes collected at 15h. Fig. 1.2 s
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In this experiment a Ti at Ni
2018-11-14
In this experiment, a Ti-50.07at%Ni sheet of 0.22mm in thickness was used. Strips of 40mm×5mm were prepared from the NiTi sheet. The samples were annealed at 1123K for 1h in vacuum. Then, a Ni thin film of ~500nm in thickness was deposited on the samples by means of DC magnetron sputtering under arg
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Further the unique neurobiological and developmental changes
2018-11-14
Further, the unique neurobiological and developmental changes that occur over the adolescent period particularly mandate study of the relationship between order SP 600125 development and mindfulness using a truly within-subjects longitudinal design. The current study examined the association betwee
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Dysregulated fear reflects a lack of modulation
2018-11-14
Dysregulated fear reflects a lack of modulation of fear across contexts (Buss, 2011). Greater dysregulated fear is associated with longer, more intense expressions of fear in both high-threat and low-threat contexts. High levels of fearfulness in low threat contexts, in particular, distinguish dysre
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A number of studies have examined the
2018-11-14
A number of studies have examined the heritability of Fmoc-O-Phospho-Tyr-OH imaging phenotypes, again mostly using twin designs. Global measures, such as brain volume (Baaré et al., 2001), gray matter volume (Baaré et al., 2001), and both surface area and thickness of the cortex (Panizzon et al., 2
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Introduction A robust estimate of DOA of
2018-11-13
Introduction A robust estimate of DOA of a seismic source is usually accomplished using an array of seismic geophones at a relatively large distance from the source [1–10]. Bearing information can also be obtained using a single geophone with three orthogonal sensing elements that provide polarizat
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In this paper the proposed
2018-11-13
In this paper, the proposed device, is basically a microtransformer constituted by a primary coil and two secondary coils connected in a differential configuration: the magnetic field generated by the primary coil, induces, at the secondary coils, voltages equal and opposite [9,12]. The approach al
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