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Hepatic drug metabolizing enzymes and transporters expressio
2022-04-12

Hepatic drug-metabolizing nampt inhibitor and transporters expression were regulated by nuclear receptors [19], [20], [21]. The effects of HFD-induced fatty liver on drug metabolizing enzymes in mice were recently studied, and the results provided a systematic evaluation of the changes of nuclear re
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Gastric inhibitory polypeptide a hormone belonging
2022-04-12

Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression
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The effect of exercise on plasma
2022-04-12

The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon
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adrenergic receptors Given the important role of Cx in maint
2022-04-12

Given the important role of Cx43 in maintaining the function of gap junctions, to investigate the effects of stress on Cx43 may be an important step towards understanding the mechanism underlying CUS-induced dysfunction of gap junctions. Corticosterone (CORT), as an important stress hormone, has bee
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The Notch cleavage efficiency of Aph aS containing complexes
2022-04-12

The Notch-cleavage efficiency of Aph1aS containing complexes was lower than that of Aph1aL γ-secretases, especially in combination with PS2, suggesting that Aph1aS is a determinant of low Notch-cleavage specificity, considering that the different subcellular localization of PS1 and PS2 didn't affect
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Conclusion By generating high quality hypocotyl transcriptom
2022-04-12

Conclusion By generating high-quality hypocotyl transcriptomes of a jute hypocotyl-defect mutant and its wild-type comprising the largest number of annotated unigenes (39,076), we identified a complete array of structurally and functionally diverse β-galactosidases. Our proposed domain-centric clas
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DNAzymes a series of nucleotide
2022-04-12

DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN
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The current gold standard for diagnosing BAM or BAD is
2022-04-12

The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) fiin (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taurocholic acid and measu
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These observations are of particular interest in
2022-04-12

These observations are of particular interest in the context of recent conceptual changes regarding the mechanisms by which different types of leukocytes contribute to atherogenesis. Over the last decade, the paradigm of the predominant circulatory origin of lesional macrophages has been challenged
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br Dynamic Localization of Hippo Pathway Components The
2022-04-11

Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i
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br Conclusion br Conflict of interest Please
2022-04-11

Conclusion Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Exotic species such as hedgehogs are becoming popular companion animals. Therefore, they are more commonly seen in veterinary clinics. Acariasis is fairly common in these animals, us
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In this new therapeutic era nucleic acid
2022-04-11

In this new therapeutic era, nucleic Tetraethylammonium chloride amplification tests (NAATs) remain critically useful. NAATs are recommended to detect HCV RNA in blood following initial serologic diagnosis of HCV infection, to distinguish between spontaneous resolution and progression to chronic in
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Although NO may act as
2022-04-11

Although, NO2− may act as the substrate for NO biosynthesis no strict correlation between NO2− fluctuation in roots and NO content was observed in tomato roots. As the culture period was prolonged NO2− concentration declined in control and m-Tyr exposed seedlings, and finally its concentration was s
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Cichlasoma dimerus as most teleost fish species present neur
2022-04-11

Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most CHIR-98014 australia species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the PO
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Piceatannol Considerable evidence links sustained GCG admini
2022-04-09

Considerable evidence links sustained GCG administration to the reduction of food intake, enhancement of energy expenditure and weight loss in rodent and human studies [16], [17], [18]. Moreover, patients presenting with GCG-producing tumors frequently manifest severe weight loss, through mechanisms
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