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br Experimental Procedures br Author Contributions br Acknow
2021-04-01
Experimental Procedures Author Contributions Acknowledgments We acknowledge Géraldine Le Goff and Mathieu Canales for blood sampling, Cécile Gameiro and Jean-Pierre Aubry for flow cytometry technical assistance, Giuseppe Pantaleo for support, and Britta Engelhardt, Gisella Puga-Young, Nicol
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Programmed cellular death or apoptosis is a process genetica
2021-04-01
Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s
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UBA belongs to the non canonical E enzymes that
2021-04-01
UBA5 belongs to the non-canonical E1 enzymes that lack a defined Cys domain but have the active-site Cys within the adenylation domain [24]. Similar to other E1 enzymes, UBA5's adenylation domain comprises an eight-stranded beta sheet that is surrounded by helices [21]. Moreover, like the ancestral
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In a study carried out by Aunis et al the
2021-04-01
In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in Vicriviroc maleate to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots
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Previous studies have indicated that
2021-04-01
Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho
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While the mechanism of DHODH inhibition induced differentiat
2021-04-01
While the mechanism of DHODH inhibition-induced differentiation is not fully understood, this phenomenon may be caused by pyrimidine depletion. Pyrazofurin, an inhibitor of OMP decarboxylase, was able to induce differentiation and suggests pyrimidine depletion as a potential mechanism (Sykes et al.,
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The sequence identity of CYP A with CYP A
2021-03-31
The sequence identity of CYP3A163 with CYP3A sequences from other species is maximum in reptiles ranging (75-91)%, gradually decreasing from l nmma (63-71)% to mammals 62% to downwards based on evolutionary distances. The high level of homology with CYP3A77 in Alligator mississippiensis suggest tha
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To assess which export pathway is used by
2021-03-31
To assess which export pathway is used by the iNOS mRNA, we inhibited CRM1 activity by incubation of DLD-1 2hcl with LMB. Since LMB covalently and exclusively binds to CRM1, it represents a potent and specific inhibitor of the CRM1 transport activity [38]. Inhibition of CRM1 activity as well as siR
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This study evaluated the role of SERT in classica
2021-03-31
This study evaluated the role of SERT in classical fear conditioning using a SERT knockout rat model. We found a clear disruption of cue-conditioned fear in SERT−/− rats, as measured with the fear-potentiated startle. This disruption was due to a deficit in fear acquisition and was accompanied by de
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In these tables the AAD
2021-03-31
In these tables, the AAD for most of the alcohols in 2B and 3B schemes is less than 1%. It should also be said that for ethanol, AAD in 2B scheme is (0.36%) and for 3B scheme it is (0.02%), which indicates superior prediction of 3B scheme compared to 2B in CPA ƒ-theory model. Table 8a, Table 9 show
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Since protein kinase CK has over known substrates
2021-03-31
Since protein kinase CK2 has over 300 known substrates we examined if the inhibitory effects described above could also be detected using another substrate. Therefore, we employed the synthetic peptide RRRADDSDDDDD which is often used in CK2 inhibitory studies. Quite contrary to the phosphorylation
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Alzheimer s disease AD is a chronic progressive neurodegener
2021-03-31
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder of the merestinib which is considered a leading cause of dementia and affects 20–30 million people worldwide. Presently, a suitable treatment and prevention strategy against AD is hardly available. Various studies have be
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In a recent report Yoshihara and colleagues used
2021-03-31
In a recent report, Yoshihara and colleagues (2016) used transcriptomes derived from freshly isolated islets of 2-week-old neonatal, 6-week-old young adult, or 12-week-old adult mice to interrogate how maturation is regulated to acquire glucose responsiveness. The authors observed that estrogen-rela
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Diagnosis of NCC can be
2021-03-31
Diagnosis of NCC can be accomplished via imaging techniques and serological confirmatory testing. The best immunodiagnostic test for NCC, the enzyme-linked immunotransfer blot EITB (Tsang et al., 1989), is based on the detection of (Z)-4-Hydroxytamoxifen to one or more of the 7 lentil-lectin glycop
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beta-Nicotinamide mononucleotide receptor Increasing evidenc
2021-03-31
Increasing evidence supports that the B-cell lymphoid malignancies develop from various stages of B-cells, hijacking the mechanisms that drive B-cell differentiation and activation [27]. For instance, mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) originate from the pre-germinal c
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