• Taking a pragmatic approach with a view

  2021-05-11

  

  Taking a pragmatic approach with a view to complete the study and because chemotherapy regimens in NETs are not standardized, we do not impose a specific regimen in both arms. However, one regimen in each arm is recommended in order to reduce heterogeneity: the ALKY-based chemotherapy arm will recei

• Cilengitide Extracellular uridine can be transported across

  2021-05-11

  

  Extracellular uridine can be transported across the cell membrane to enter the nucleotide salvage pathway. A colon cancer cell line supplemented with uridine was capable of growing normally in the presence of 1 μM brequinar (Peters et al., 1992). The supplemented uridine may be transported into the

• Some mechanistic experiments performed in

  2021-05-11

  

  Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects 4-IPP receptor from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This ev

• br Introduction Cardiovascular disease continues

  2021-05-11

  

  Introduction Cardiovascular disease continues to be the leading cause of death in developed countries. Atherosclerosis, a chronic inflammatory cardiovascular disease, is characterized by the progressive buildup of oxidized low density lipoproteins in the arterial walls (Ross, 1999). In the develo

• In conclusion by investigating the cysteine protease

  2021-05-11

  

  In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070

• Introduction Cytochrome P CYP A is the most important

  2021-05-11

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The Cilostazol receptor level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxi

• Here we show that cpg is expressed only in

  2021-05-10

  

  Here, we show that cpg2 is expressed only in the tachykinin and encodes a protein that localizes specifically to the postsynaptic endocytic zone of excitatory synapses. We present evidence that CPG2 is a critical component of the postsynaptic endocytic pathway that mediates both constitutive and ac

• br Patients and methods br Results Table shows relevant

  2021-05-10

  

  Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu

• The T cell receptor TCR pathway is

  2021-05-10

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• PGE EP activation has been found to attenuate the activation

  2021-05-10

  

  PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced Raltitrexed sale inflammation [15]. Moreover, PGE2/EP4 signaling has elicited a protective functio

• (-)-Bicuculline methiodide br Mass spectrometry based techno

  2021-05-10

  

  Mass spectrometry-based technologies Oxysterols tend not to be observed in global lipidomic analysis, whether shot-gun based electrospray ionisation – mass spectrometry (ESI-MS) or liquid chromatography (LC)-MS based. This is because of their comparatively low-abundance and poor ionisation charac

• One of the isolated interactors against Mulan Ube

  2021-05-10

  

  One of the isolated interactors against Mulan259–352–Ube2E3 fusion bait was found to be the GABARAP protein, a known member of the Atg8 family that includes LC3 [20]. The Atg8 family-of-proteins are major players in autophagy/mitophagy since they are part of the autophagosome [20], [21], [22]. Our s

• Compstatin br Acknowledgements br Introduction Lung cancer t

  2021-05-10

  

  Acknowledgements Introduction Lung cancer treatment strategies, especially molecular targeted therapy, have progressed rapidly. However, most established treatments are for adenocarcinoma of the lung, not for squamous cell carcinoma (SQCC). SQCC constitutes approximately 30% of lung cancers, w

• The aim of this study was to evaluate the

  2021-05-10

  

  The aim of this study was to evaluate the role of aberrant methylation of promoter regions of tumor suppressor genes in the clonal evolution from MGUS to MM. Thus, we analyzed in MGUS, SMM, and symptomatic MM patients, the methylation status of 4 genes—p15, p16, p53, and DAPK—whose promoter hypermet

• It is worth mentioning that in this

  2021-05-10

  

  It is worth mentioning that, in this study we only observed the responses of CYP450 to the short-term exposure of DSP toxins (12 h). However, the toxic effects of DSP toxins to bivalves appeared to abate with longer exposure (Pinto-Silva et al., 2005; Flórez-Barrós et al., 2011; Prego-Faraldo et al.

15965 records 654/1065 page Previous Next First page 上5页 651652653654655 下5页 Last page