• A rational approach for the

  2024-10-12

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

• br Materials and methods br Results To explore the

  2024-10-12

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the ITF 2357 of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression of p62 was revealed

• cysteine protease inhibitor PF also a dual Aurora A and Auro

  2024-10-12

  

  PF-03814735, also a dual Aurora-A and Aurora-B inhibitor, was administered in a phase I dose escalation study in a 3-weekly cysteine protease inhibitor for 5 or 10 consecutive days [69], [70]. To date 25 patients have been included in 7 dose levels (5–100mg/day for 5 days). Using the 5-day schedule

• Zhang et al screened three thousand compounds

  2024-10-12

  

  Zhang et al. screened three thousand compounds library and found two active 3,5,6-substituted indolin-2-one molecules. Further, they designed various derivatives of this scaffold and among them compound 23 from the series was found active with 1.8 μM on Aurora-B kinase luminescent assay [53]. Jeffe

• In addition to pH regulation by ion counter fluxes

  2024-10-12

  

  In addition to pH regulation by ion (counter-) fluxes, acidification is regulated by the abundance of V-ATPase on organelles, by the pumping activity of the complex and by proton leakage. In yeast, the V-ATPase VO subunit a is the only subunit expressed in two isoforms termed Stv1p and Vph1p. V-ATPa

• We showed that activation of the ATM ATR pathway leads

  2024-10-12

  

  We showed that activation of the ATM/ATR pathway leads to over-replication through suppression of CDK1 activity, consistent with previous findings that suppression of CDK1 activity is involved in the polyploidization of megakaryocyte and trophoblast cells [36], [37], [38], [39]. Suppression of CDK1

• This study evaluated the anti

  2024-10-12

  

  This study evaluated the anti-tumor influences of LA against HepG2 rt pcr steps in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondrial-

• br Conflict of interest br Introduction

  2024-10-12

  

  Conflict of interest Introduction Platelets are anucleate blood cells essential for hemostasis and wound healing; tight regulation of platelet numbers is crucial for human health. Platelets are synthesized and released from bone marrow megakaryocytes into the circulation where they remain for

• br Apelin The APJ receptor ligand apelin firstly

  2024-10-12

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino Betamethasone Dipropionate residues that are cleaved into biologically active C-terminal fragmen

• Since E was shown to affect the expression of Hsps

  2024-10-12

  

  Since E2 was shown to affect the expression of Hsps, the transcript expression levels of another 11 Hsps were also evaluated by real-time PCR with their specific primers. The transcripts of 4 proteins (Hsp10, Hsp56, Hsp70a and Hsp110) were significantly up-regulated, but that of Hsp47 was significan

• br Experimental procedures br Results

  2024-10-11

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this methane monooxygenase work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would

• hbv The control group participants of the current study were

  2024-10-11

  

  The control group participants of the current study were very similar in age to those of Puertas et al. There was no significant correlation between age and enzyme activity over the short age span studied although age-related changes in the activity of ApA and aspartyl aminopeptidase, typically incr

• To date defining the prognostic

  2024-10-11

  

  To date, defining the prognostic impact of molecular drivers of early-stage NSCLC has been challenging due to the relative rarity of these subsets and the redefinition of comparator arms over time as understanding of the molecular drivers of NSCLC evolved. Indeed, use of molecularly heterogeneous co

• The AHR potentially enhances IDO expression

  2024-10-11

  

  The AHR potentially enhances IDO-expression, possibly via crosstalk with several inflammatory signaling pathways (shown by now for IL6 and ‘signal transducer and activator of transcription’ (STAT) 3, and for NFκB, toll like receptor-pathways) [56,59,60]. IDO metabolizes Trp to kynurenines, which are

• In fact serotonin is a major modulator of

  2024-10-11

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

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