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The cysteinyl leukotrienes cysLTs LTC LTD and
2019-07-02
The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the e
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The UPR is composed of
2019-07-02
The UPR is composed of three different pathways that fall under the control of three respective ER transmembrane proteins: PERK, IRE1α (inositol-requiring enzyme 1α) and ATF6 (activating transcription factor 6). As a starting signal for the UPR, misfolded proteins induce the release of GRP78 from th
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In contrast to chordates authentic
2019-07-02
In contrast to chordates, authentic chemokine and receptor orthologues can be found in the agnathan fishes (Bajoghli, 2013, Kuroda et al., 2003, Nomiyama et al., 2011, Nomiyama et al., 2013); sea lamprey has at least five chemokine receptor genes, one CXCR4 (Ensembl Acc. No.: ENSPMAP00000007678) (Ku
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DDX belongs to the DEAD box family of proteins ATP
2019-07-02
DDX3 belongs to the DEAD-box family of proteins, ATP-dependent RNA helicases characterized by the presence of a highly conserved helicase core domain [13]. This catalytic core is composed of two RecA-like domains containing motifs involved in ATP binding/hydrolysis, RNA binding and helicase activity
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The intricate roles and neural systems and mechanisms
2019-07-02
The intricate roles and neural systems and mechanisms involved in the CRF1 and CRF2 mediation of spontaneous and stress-induced anxiety behavior remain to be defined. Of particular relevance are studies evaluating the behavioral actions of CRF1 and CRF2 receptors separately as well as together. For
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br Experimental br Results and discussion On the basis of
2019-07-02
Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it Fructose Colorimetric/Fluorometric Assay Kit of is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was
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Which other approaches can complement signaling optogenetics
2019-07-02
Which other approaches can complement signaling optogenetics to paint a more complete picture of developmental Erk signaling? For now, the authors have dynamically manipulated Erk signaling but measured the Erk output at steady-state using classic immunofluorescence techniques (Johnson and Toettcher
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cAMP mediated signaling pathways are important
2019-07-02
cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, NSC228155 structure of the PKA 2β regulatory subunit (RIIβ) in mice leads to increased expr
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br Results br Discussion In
2019-07-02
Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer Alsterpaullon
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Introduction PGE is a major mediator present at sites of
2019-07-02
Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 Triptolide were able to reverse the swelling and pain in l
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Nitric oxide synthase NOS is a
2019-07-02
Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino ONX-0914 molecular arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, among an array of othe
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Therapeutic options targeting intrahepatic resistance are ve
2019-07-01
Therapeutic options targeting intrahepatic resistance are very limited. Theoretically, the NO-cGMP pathway may be influenced at several sites. Yet, most strategies did not reach clinical practice or yielded disappointing results, such as activators of soluble guanylate cyclase [14], NO releasing der
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Conflicting findings have been reported on
2019-07-01
Conflicting findings have been reported on the survival and function recovery between treatments of LSS and amputation in patients with osteosarcoma. Toward this end, a meta-analysis of published clinical trials was performed to compare the clinical efficacy of LSS and amputation treatments in terms
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La irrupci n del invierno en el lugar que fue
2019-07-01
La irrupción del invierno en el “lugar que fue nuestro” es un motivo de lamentación melancólica porque estorba la dicha del yo lírico. La llegada de la nueva temporada se expresa con una referencia explícita al comienzo del invierno en el primer verso y una evocación de “las bandadas que emigran”. E
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El fuego como paradoja de la persistencia y
2019-07-01
El fuego como paradoja de la persistencia y del cambio Penetrar la cosmología poética de José Emilio Pacheco supone enfrentarse Schisandrol B what la paradoja entre la persistencia de la materia y su transformación. El signo global que fecunda la dinámica expresiva de la escritura en este caso es e
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