• ICLs represent of all generated DNA adducts

  2022-05-27

  

  ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr

• br Acknowledgments This review is based in part

  2022-05-27

  

  Acknowledgments This review is based in part on research conducted with financial support from the General Research Fund (17112914) of the Hong Kong Research Grant Council and from the Seed Funding Programme for Basic Research by University Research Committee of the University of Hong Kong (20151

• It has been known for some time that

  2022-05-27

  

  It has been known for some time that an oral salt load given to mammals induces a much greater natriuresis than the intravenous administration of an equivalent amount of saline (Carey et al., 1976, Singer et al., 1998). In addition, oral administration of salt to rats has been reported to augmented

• The following are the supplementary data related to this

  2022-05-27

  

  The following are the supplementary data related to this article. Transparency Document Acknowledgements Introduction Nitric oxide (NO) is an important signaling molecule mediating several physiological functions including vasodilation, platelet anti-aggregation, inhibition of interstitial

• We were able to obtain

  2022-05-26

  

  We were able to obtain several crystalline forms of CHAV Gth. The first one corresponded to the post-fusion conformation [14]. The comparison of this structure with that of VSV-Gth post-fusion conformation revealed that the PHD is the most divergent domain, with the largest differences confined to t

• LFFs associating with green algae utilize polyols

  2022-05-26

  

  LFFs associating with green algae utilize polyols; therefore, we hypothesize that at least one polyol transport system is conserved in LFFs and it is required for the lichenization events that occur widely and independently in Ascomycota. Thus, the present study aimed to first evaluate phylogenetic

• Increasing evidence has shown that

  2022-05-26

  

  Increasing evidence has shown that blockade of glutamate uptake leads to aberrant behavioral consequences. For example, intracerebroventricular (i.c.v) injection or microinjection of the GLT-1 inhibitor, dihydrokainic sevelamer hcl receptor (DHK), into the prefrontal cortex induces anhedonia [8,9].

• br Materials and methods br Results Aberrant A

  2022-05-26

  

  Materials and methods Results Aberrant Aβ has been suggested to be an initiating factor for glutamate excitotoxicity in AD pathology. To investigate whether Aβ1-42 alters glutamate uptake in astrocytes, neurons, and astrocyte-neuron co-cultures, we used synthetic Aβ1-42 peptide. Aβ1-42 has fas

• LbGlcK and the HsHxKIV d glucose complex PDB entry

  2022-05-26

  

  LbGlcK and the HsHxKIV-d-glucose complex (PDB entry 3IDH) [17] were superimposed from individual subunits. The active site regions revealed the key Nifedipine binding residues to be present for LbGlcK; also, the superposition showed that HsHxKIV had residues that were absent in LbGlcK, such as K169

• LbGlcK crystallized as a ligandless dimer in the asymmetric

  2022-05-26

  

  LbGlcK crystallized as a ligandless dimer in the asymmetric unit of space group P21 (Fig. 1a) with two identical subunits stabilized by a large contact surface area of 2295 Å2 (13% of the total surface area) as determined by the Protein Interfaces, Surfaces, and Assemblies (PISA) server [18]. Each m

• In Solloway and colleagues reported that mice with alpha

  2022-05-26

  

  In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino Spectinomycin hydrochloride hydrate dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanisti

• br NLS and NES Mapping br Sequence

  2022-05-26

  

  NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino Sorbitol residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the intervening amino acid s

• Recently unimolecular multi functional peptides that combine

  2022-05-26

  

  Recently, unimolecular, multi-functional peptides that combine GLP-1RA activity with Phos-tag and/or GIP activity have been suggested as new therapeutic agents for glycaemic and weight control. In rodents, dual GIP and GLP-1 receptor agonists achieve significantly better glucose control and weight

• Although the ramifications of non

  2022-05-26

  

  Although the ramifications of non-additive SAR are context-dependent, the knowledge that perturbations in one region of a chemical series are not synergistic with perturbations in another region of the same chemical series is clearly pertinent to any medicinal chemistry effort. In our experience, n

• p53 apoptosis Emergent studies have recently shown that Sher

  2022-05-26

  

  Emergent studies have recently shown that Sherpas living at high altitude have adaptations that make life at high altitude more compatible. Sherpas are known to have blood Hb concentrations about the same as lowlanders and Han populations [30]. This is different from what happens to lowlanders, Han

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